Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing

Jennifer M Fitzpatrick, Karl F Hoffmann

Research output: Contribution to journalArticlepeer-review

51 Citations (SciVal)

Abstract

Pairing of adult Schistosoma mansoni parasites initiates a cascade of events including mating and egg production that ultimately leads to immuno-pathological lesions during schistosomiasis. To identify genes associated with this important biological process, we studied parasites isolated from single- versus mixed-sex cercariae-infected mice using DNA microarray analysis to uncover pair-regulated transcriptional profiles. We report that: (i) transcriptomes of parasites isolated from single-sex infections are significantly more complex than their mixed-sex counterparts; (ii) transcriptomes of single-sex males are distinct from mixed-sex males; and (iii) not all transcripts, previously hypothesized to be critical in female egg production, are regulated by pairing.
Original languageEnglish
Pages (from-to)1081-1089
Number of pages9
JournalInternational Journal for Parasitology
Volume36
Issue number10-11
Early online date10 Jul 2006
DOIs
Publication statusPublished - 01 Sept 2006

Keywords

  • transcriptome
  • Schistosoma
  • gene expression
  • blood fluke

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