Abstract
Pairing of adult Schistosoma mansoni parasites initiates a cascade of events including mating and egg production that ultimately leads to immuno-pathological lesions during schistosomiasis. To identify genes associated with this important biological process, we studied parasites isolated from single- versus mixed-sex cercariae-infected mice using DNA microarray analysis to uncover pair-regulated transcriptional profiles. We report that: (i) transcriptomes of parasites isolated from single-sex infections are significantly more complex than their mixed-sex counterparts; (ii) transcriptomes of single-sex males are distinct from mixed-sex males; and (iii) not all transcripts, previously hypothesized to be critical in female egg production, are regulated by pairing.
Original language | English |
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Pages (from-to) | 1081-1089 |
Number of pages | 9 |
Journal | International Journal for Parasitology |
Volume | 36 |
Issue number | 10-11 |
Early online date | 10 Jul 2006 |
DOIs | |
Publication status | Published - 01 Sept 2006 |
Keywords
- transcriptome
- Schistosoma
- gene expression
- blood fluke