DIVA reagents for bovine tuberculosis vaccines in cattle

Martin Vordermeier; Gareth J. Jones; Adam O. Whelan

doi:10.1586/erv.11.22

DIVA reagents for bovine tuberculosis vaccines in cattle

Martin Vordermeier, Gareth J. Jones, Adam O. Whelan

Animal and Plant Health Agency

Research output: Contribution to journal › Review article › peer-review

Abstract

Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.

Original language	English
Pages (from-to)	1083-1091
Number of pages	9
Journal	Expert Review of Vaccines
Volume	10
Issue number	7
DOIs	https://doi.org/10.1586/erv.11.22
Publication status	Published - 01 Jul 2011

Keywords

biomarkers
bovine tuberculosis
cattle
diagnosis
DIVA
vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1586/erv.11.22

Permanent link

Persistent link

Cite this

@article{156fbc0131ee4f38bbcece92eef1ea91,

title = "DIVA reagents for bovine tuberculosis vaccines in cattle",

abstract = "Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.",

keywords = "biomarkers, bovine tuberculosis, cattle, diagnosis, DIVA, vaccination",

author = "Martin Vordermeier and Jones, {Gareth J.} and Whelan, {Adam O.}",

year = "2011",

month = jul,

day = "1",

doi = "10.1586/erv.11.22",

language = "English",

volume = "10",

pages = "1083--1091",

journal = "Expert Review of Vaccines",

issn = "1476-0584",

publisher = "Taylor & Francis",

number = "7",

}

TY - JOUR

T1 - DIVA reagents for bovine tuberculosis vaccines in cattle

AU - Vordermeier, Martin

AU - Jones, Gareth J.

AU - Whelan, Adam O.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.

AB - Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.

KW - biomarkers

KW - bovine tuberculosis

KW - cattle

KW - diagnosis

KW - DIVA

KW - vaccination

UR - http://www.scopus.com/inward/record.url?scp=80051484075&partnerID=8YFLogxK

U2 - 10.1586/erv.11.22

DO - 10.1586/erv.11.22

M3 - Review article

C2 - 21806401

AN - SCOPUS:80051484075

SN - 1476-0584

VL - 10

SP - 1083

EP - 1091

JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

IS - 7

ER -

DIVA reagents for bovine tuberculosis vaccines in cattle

Abstract

Keywords

UN SDGs

Access to Document

Permanent link

Other files and links

Fingerprint

Cite this