DIVA reagents for bovine tuberculosis vaccines in cattle

Martin Vordermeier; Gareth J. Jones; Adam O. Whelan

doi:10.1586/erv.11.22

DIVA reagents for bovine tuberculosis vaccines in cattle

Martin Vordermeier^*, Gareth J. Jones, Adam O. Whelan

^*Corresponding author for this work

Animal and Plant Health Agency

Research output: Contribution to journal › Review Article › peer-review

33 Citations (Scopus)

Abstract

Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.

Original language	English
Pages (from-to)	1083-1091
Number of pages	9
Journal	Expert Review of Vaccines
Volume	10
Issue number	7
DOIs	https://doi.org/10.1586/erv.11.22
Publication status	Published - 01 Jul 2011

Keywords

biomarkers
bovine tuberculosis
cattle
diagnosis
DIVA
vaccination

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.",

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AB - Significant progress has been made in the development of specific antigens that allow the differentiation of BCG-vaccinated and Mycobacterium bovis-infected cattle (the differential diagnosis of infected from vaccinated individuals test). This has been greatly facilitated by the completion of the genome sequences of Mycobacterium tuberculosis, M. bovis and BCG Pasteur and the application of comparative genome and transcriptome analysis to define differentiating infected from vaccinated animals (DIVA) antigens that complement the prototype DIVA antigens ESAT-6 and CFP-10. In this article we present an update of our current approaches including the search for stage-specific antigens, the identification of novel diagnostic biomarkers and the development of DIVA skin tests. We also discuss the possible cost-effective application of DIVA tests within the remits of a cattle BCG vaccine program.

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KW - cattle

KW - diagnosis

KW - DIVA

KW - vaccination

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DIVA reagents for bovine tuberculosis vaccines in cattle

Abstract

Keywords

UN SDGs

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