TY - JOUR
T1 - Effects of bovine colostrum supplementation on upper respiratory illness in active males
AU - Jones, Arwel W.
AU - Cameron, Simon J. S.
AU - Thatcher, Rhys
AU - Beecroft, Marikka Shannon
AU - Mur, Luis A. J.
AU - Davison, Glen
N1 - Jones, A. W., Cameron, S. J. S., Thatcher, R., Beecroft, M. S., Mur, L. A. J., Davison, G. (2014). Effects of bovine colostrum supplementation on upper respiratory illness in active males. Brain, Behavior, and Immunity, 39, 194-203
Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2014/7
Y1 - 2014/7
N2 - Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction and increased risk of upper respiratory illness (URI) in athletic populations, however, the mechanisms remain unclear. During winter months, under double-blind procedures, 53 males (mean training load±SD, 50.5±28.9 MET-hweek(-1)) were randomized to daily supplementation of 20g of COL (N=25) or an isoenergetic/isomacronutrient placebo (PLA) (N=28) for 12weeks. Venous blood was collected at baseline and at 12weeks and unstimulated saliva samples at 4 weeks intervals. There was a significantly lower proportion of URI days and number of URI episodes with COL compared to PLA over the 12weeks (p0.05), which does not support previously suggested mechanisms. In a subset of participants (COL=14, PLA=17), real-time quantitative PCR, targeting the 16S rRNA gene showed there was an increase in salivary bacterial load over the 12 weeks period with PLA (p
AB - Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction and increased risk of upper respiratory illness (URI) in athletic populations, however, the mechanisms remain unclear. During winter months, under double-blind procedures, 53 males (mean training load±SD, 50.5±28.9 MET-hweek(-1)) were randomized to daily supplementation of 20g of COL (N=25) or an isoenergetic/isomacronutrient placebo (PLA) (N=28) for 12weeks. Venous blood was collected at baseline and at 12weeks and unstimulated saliva samples at 4 weeks intervals. There was a significantly lower proportion of URI days and number of URI episodes with COL compared to PLA over the 12weeks (p0.05), which does not support previously suggested mechanisms. In a subset of participants (COL=14, PLA=17), real-time quantitative PCR, targeting the 16S rRNA gene showed there was an increase in salivary bacterial load over the 12 weeks period with PLA (p
KW - URTI
KW - innate immunity
KW - mucosal immunity
KW - microbiome
KW - 16S rRNA
KW - metabolomics
UR - http://hdl.handle.net/2160/13129
U2 - 10.1016/j.bbi.2013.10.032
DO - 10.1016/j.bbi.2013.10.032
M3 - Article
C2 - 24200515
SN - 0889-1591
VL - 39
SP - 194
EP - 203
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -
