European 2 - A clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula

Sabrina Rodriguez-Campos, Anita C. Schürch, James Dale, Amanda J. Lohan, Mónica V. Cunha, Ana Botelho, Krystel De Cruz, M. Laura Boschiroli, M. Beatrice Boniotti, Maria Pacciarini, M. Carmen Garcia-Pelayo, Beatriz Romero, Lucía de Juan, Lucas Domínguez, Stephen V. Gordon, Dick van Soolingen, Brendan Loftus, Stefan Berg, R. Glyn Hewinson, Alicia Aranaz*Noel H. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (SciVal)


Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.

Original languageEnglish
Pages (from-to)866-872
Number of pages7
JournalInfection, Genetics and Evolution
Issue number4
Publication statusPublished - 01 Jun 2012


  • Clonal complex
  • Europe
  • Mycobacterium bovis
  • Phylogeny
  • Whole genome sequencing


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