Abstract
Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.
Original language | English |
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Pages (from-to) | 866-872 |
Number of pages | 7 |
Journal | Infection, Genetics and Evolution |
Volume | 12 |
Issue number | 4 |
DOIs | |
Publication status | Published - 01 Jun 2012 |
Keywords
- Clonal complex
- Europe
- Mycobacterium bovis
- Phylogeny
- Whole genome sequencing