TY - JOUR
T1 - Experimental infection models of tuberculosis in domestic livestock
AU - Buddle, Bryce M.
AU - Vordermeier, H. Martin
AU - Hewinson, R. Glyn
PY - 2016/8/26
Y1 - 2016/8/26
N2 - In this article we present experimental Mycobacterium bovis infection models in domestic livestock species and how these models were applied to vaccine development, biomarker discovery, and the definition of specific antigens for the differential diagnosis of infected and vaccinated animals. In particular, we highlight synergies between human and bovine tuberculosis (TB) research approaches and data and propose that the application of bovine TB models could make a valuable contribution to human TB vaccine research and that close alignment of both research programs in a one health philosophy will lead to mutual and substantial benefits.
AB - In this article we present experimental Mycobacterium bovis infection models in domestic livestock species and how these models were applied to vaccine development, biomarker discovery, and the definition of specific antigens for the differential diagnosis of infected and vaccinated animals. In particular, we highlight synergies between human and bovine tuberculosis (TB) research approaches and data and propose that the application of bovine TB models could make a valuable contribution to human TB vaccine research and that close alignment of both research programs in a one health philosophy will lead to mutual and substantial benefits.
UR - http://www.scopus.com/inward/record.url?scp=85011593421&partnerID=8YFLogxK
U2 - 10.1128/microbiolspec.TBTB2-0017-2016
DO - 10.1128/microbiolspec.TBTB2-0017-2016
M3 - Article
C2 - 27726786
AN - SCOPUS:85011593421
SN - 2165-0497
VL - 4
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 4
M1 - TBTB2-0017-2016
ER -
