Abstract
his review focuses on the regulatory functions of IL-10 in the response to parasitic and
bacterial infection revealed through knockout, cytokine/receptor blocking, and
transgenic mouse studies. The various mechanisms that control the production and
activity of IL-10 are also discussed. Studies performed over the past few years illustrate a complex
and pleiotropic nature for IL-10 in host immunity. The fact that nearly every cell in the
body can respond to IL-10 and multiple cells produce the cytokine likely explains this multifaceted
activity. Studies conducted in experimental infectious and inflammatory diseases models
have been particularly useful in defining the various regulatory activities of IL-10. Although
these studies have identified many common themes for IL-10 in host immunity, they also
nicely illustrate how IL-10 fine-tunes the response to individual pathogens and prevents inflammation.
Original language | English |
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Title of host publication | Interleukin-10 |
Editors | Francesco M. Marincola |
Publisher | Taylor & Francis |
ISBN (Print) | 978-1587062858, 1587062852 |
Publication status | Published - 26 Jan 2006 |