Explanatory optimization of protein mass spectrometry via genetic search

Royston Goodacre, S. Vaidyanathan, David Iain Broadhurst, Douglas B. Kell

Research output: Contribution to journalArticlepeer-review

40 Citations (SciVal)

Abstract

Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of
Original languageEnglish
Pages (from-to)6679-6686
Number of pages8
JournalAnalytical Chemistry
Volume75
Issue number3
DOIs
Publication statusPublished - 25 Oct 2003

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