Extending an established simulation: Exploration of the possible effects using a case study in experimental autoimmune encephalomyelitis

Richard B. Greaves*, Mark Read, Jon Timmis, Paul S. Andrews, Vipin Kumar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

4 Citations (SciVal)

Abstract

Investigation of a biological domain through simulation can naturally lead to the desire to extend the simulation as new areas of the domain are explored. Such extension may entail the incorporation of additional cell types, molecules or entire molecular pathways. The addition of these extensions can have a profound influence on simulation behaviour, and where the biological domain is not well characterised, a structured development methodology must be employed to ensure that the extended simulation is well aligned with its predecessor. The paper presents such a methodology, relying on iterated development and sensitivity analysis, by extending an existing simulation of Experimental Autoimmune Encephalomyelitis (EAE), a disease model for Multiple Sclerosis, via inclusion of an additional regulatory pathway. We reflect on the implications of extensions which alter simulation behaviour on pre-extension results.

Original languageEnglish
Title of host publicationInformation Processing in Cells and Tissues - 9th International Conference, IPCAT 2012, Proceedings
PublisherSpringer Nature
Pages150-161
Number of pages12
ISBN (Print)9783642287916
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event9th International Conference on Information Processing in Cells and Tissues, IPCAT 2012 - Cambridge, United Kingdom of Great Britain and Northern Ireland
Duration: 31 Mar 201202 Apr 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7223 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference9th International Conference on Information Processing in Cells and Tissues, IPCAT 2012
Country/TerritoryUnited Kingdom of Great Britain and Northern Ireland
CityCambridge
Period31 Mar 201202 Apr 2012

Keywords

  • agent-based simulation
  • Experimental Autoimmune Encephalomyelitis
  • in silico experimentation
  • Regulatory pathway

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