Abstract
We report that bilateral. excitoxic lesions of the perirhinal cortex attenuate rats' familiarity-based stimulus generalization After surgery. rats were preexposed either to 2 auditory stimuli (A and B) or to only 1 auditory stimulus (B) Following preexposure, all rats received pairings of A and a footshock before assessment of generalized responding (conditioned suppression) to B Sham rats' generalization was greater when preexposure was to both A and 13 than when preexposure was to 13 only That pattern was abolished in lesioned rats, though no general deficiency was found in other measures of auditory processing Our findings suggest that the perirhinal cortex is required for rats to encode familiarity as part of stimulus representations
Original language | English |
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Pages (from-to) | 587-599 |
Number of pages | 12 |
Journal | Behavioral Neuroscience |
Volume | 124 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2010 |
Keywords
- Generalisation decrement;
- Familarity
- Perirhinal cortex