Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta

Katarina Le Blanc, Cecilia Götherström, Olle Ringdén, Moustapha Hassan, Robert McMahon, Edwin Horwitz, Göran Anneren, Ove Axelsson, Janice Nunn, Uwe Ewald, Solveig Nordén-Lindeberg, Monika Jansson, Ann Dalton, Eva Aström, Magnus Westgren

Research output: Contribution to journalArticlepeer-review

400 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSC) are progenitors of mesenchymal tissues such as bone, cartilage, and adipose. Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results.
Original languageEnglish
Pages (from-to)1607-1614
Number of pages8
JournalTransplantation
Volume79
Issue number11
Publication statusPublished - 15 Jun 2005
Externally publishedYes

Keywords

  • Adult
  • Biopsy
  • Bone and Bones
  • Collagen
  • Collagen Type I
  • DNA Primers
  • Female
  • Fetal Tissue Transplantation
  • Gestational Age
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Humans
  • In Situ Hybridization, Fluorescence
  • Infant
  • Infant, Newborn
  • Male
  • Mesoderm
  • Osteogenesis Imperfecta
  • Pregnancy
  • Pregnancy Complications
  • Stem Cell Transplantation
  • Transplantation Chimera

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