Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta

Katarina Le Blanc; Cecilia Götherström; Olle Ringdén; Moustapha Hassan; Robert McMahon; Edwin Horwitz; Göran Anneren; Ove Axelsson; Janice Nunn; Uwe Ewald; Solveig Nordén-Lindeberg; Monika Jansson; Ann Dalton; Eva Aström; Magnus Westgren

Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta

Katarina Le Blanc
, Cecilia Götherström
, Olle Ringdén
, Moustapha Hassan
, Robert McMahon
, Edwin Horwitz
, Göran Anneren
, Ove Axelsson
, Janice Nunn
, Uwe Ewald
, Solveig Nordén-Lindeberg
, Monika Jansson
, Ann Dalton
, Eva Aström
, Magnus Westgren

Karolinska University Hospital
Sheffield Children's NHS Foundation Trust
St. Jude Children's Research Hospital
Uppsala University
Kosair Children's Hospital

Research output: Contribution to journal › Article › peer-review

430 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSC) are progenitors of mesenchymal tissues such as bone, cartilage, and adipose. Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results.

Original language	English
Pages (from-to)	1607-1614
Number of pages	8
Journal	Transplantation
Volume	79
Issue number	11
Publication status	Published - 15 Jun 2005
Externally published	Yes

Keywords

Adult
Biopsy
Bone and Bones
Collagen
Collagen Type I
DNA Primers
Female
Fetal Tissue Transplantation
Gestational Age
HLA-DR Antigens
HLA-DRB1 Chains
Humans
In Situ Hybridization, Fluorescence
Infant
Infant, Newborn
Male
Mesoderm
Osteogenesis Imperfecta
Pregnancy
Pregnancy Complications
Stem Cell Transplantation
Transplantation Chimera

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Le Blanc, K., Götherström, C., Ringdén, O., Hassan, M., McMahon, R., Horwitz, E., Anneren, G., Axelsson, O., Nunn, J., Ewald, U., Nordén-Lindeberg, S., Jansson, M., Dalton, A., Aström, E., & Westgren, M. (2005). Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation, 79(11), 1607-1614.

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title = "Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta",

abstract = "Mesenchymal stem cells (MSC) are progenitors of mesenchymal tissues such as bone, cartilage, and adipose. Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results.",

keywords = "Adult, Biopsy, Bone and Bones, Collagen, Collagen Type I, DNA Primers, Female, Fetal Tissue Transplantation, Gestational Age, HLA-DR Antigens, HLA-DRB1 Chains, Humans, In Situ Hybridization, Fluorescence, Infant, Infant, Newborn, Male, Mesoderm, Osteogenesis Imperfecta, Pregnancy, Pregnancy Complications, Stem Cell Transplantation, Transplantation Chimera",

author = "\{Le Blanc\}, Katarina and Cecilia G{\"o}therstr{\"o}m and Olle Ringd{\'e}n and Moustapha Hassan and Robert McMahon and Edwin Horwitz and G{\"o}ran Anneren and Ove Axelsson and Janice Nunn and Uwe Ewald and Solveig Nord{\'e}n-Lindeberg and Monika Jansson and Ann Dalton and Eva Astr{\"o}m and Magnus Westgren",

year = "2005",

month = jun,

day = "15",

language = "English",

volume = "79",

pages = "1607--1614",

journal = "Transplantation",

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Le Blanc, K, Götherström, C, Ringdén, O, Hassan, M, McMahon, R, Horwitz, E, Anneren, G, Axelsson, O, Nunn, J, Ewald, U, Nordén-Lindeberg, S, Jansson, M, Dalton, A, Aström, E & Westgren, M 2005, 'Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta', Transplantation, vol. 79, no. 11, pp. 1607-1614.

TY - JOUR

T1 - Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta

AU - Le Blanc, Katarina

AU - Götherström, Cecilia

AU - Ringdén, Olle

AU - Hassan, Moustapha

AU - McMahon, Robert

AU - Horwitz, Edwin

AU - Anneren, Göran

AU - Axelsson, Ove

AU - Nunn, Janice

AU - Ewald, Uwe

AU - Nordén-Lindeberg, Solveig

AU - Jansson, Monika

AU - Dalton, Ann

AU - Aström, Eva

AU - Westgren, Magnus

PY - 2005/6/15

Y1 - 2005/6/15

N2 - Mesenchymal stem cells (MSC) are progenitors of mesenchymal tissues such as bone, cartilage, and adipose. Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results.

AB - Mesenchymal stem cells (MSC) are progenitors of mesenchymal tissues such as bone, cartilage, and adipose. Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results.

KW - Adult

KW - Biopsy

KW - Bone and Bones

KW - Collagen

KW - Collagen Type I

KW - DNA Primers

KW - Female

KW - Fetal Tissue Transplantation

KW - Gestational Age

KW - HLA-DR Antigens

KW - HLA-DRB1 Chains

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Mesoderm

KW - Osteogenesis Imperfecta

KW - Pregnancy

KW - Pregnancy Complications

KW - Stem Cell Transplantation

KW - Transplantation Chimera

UR - http://hdl.handle.net/2160/12584

M3 - Article

C2 - 15940052

SN - 0041-1337

VL - 79

SP - 1607

EP - 1614

JO - Transplantation

JF - Transplantation

IS - 11

ER -

Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta

Abstract

Keywords

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