Functional complexity of the Leishmania granuloma and the potential of in silico modeling

John W.J. Moore, Daniel Moyo, Lynette Beattie, Paul S. Andrews, Jon Timmis, Paul M. Kaye*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Citations (SciVal)

Abstract

In human and canine visceral leishmaniasis and in various experimental models of this disease, host resistance is strongly linked to efficient granuloma development. However, it is unknown exactly how the granuloma microenvironment executes an effective antileishmanial response. Recent studies, including using advanced imaging techniques, have improved our understanding of granuloma biology at the cellular level, highlighting heterogeneity in granuloma development and function, and hinting at complex cellular, temporal, and spatial dynamics. In this mini-review, we discuss the factors involved in the formation and function of Leishmania donovani-induced hepatic granulomas, as well as their importance in protecting against inflammation-associated tissue damage and the generation of immunity to rechallenge. Finally, we discuss the role that computational, agent-based models may play in answering outstanding questions within the field.

Original languageEnglish
Article numberArticle 35
JournalFrontiers in Immunology
Volume4
Issue numberFRB
DOIs
Publication statusPublished - 2013

Keywords

  • Granuloma
  • Imaging
  • In silico modeling
  • Inflammation
  • Leishmaniasis
  • Visceral

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