Gene expression profiling to characterize sediment toxicity – a pilot study using Caenorhabditis elegans whole genome microarrays

Ralph Menzel, Suresh C Swain, Sebastian Hoess, Evelyn Claus, Stefanie Menzel, Christian Ew Steinberg, Georg Reifferscheid, Stephen R Stürzenbaum

Research output: Contribution to journalArticlepeer-review

69 Citations (SciVal)
189 Downloads (Pure)

Abstract

Traditionally, toxicity of river sediments is assessed using whole sediment tests with benthic organisms. The challenge, however, is the differentiation between multiple effects caused by complex contaminant mixtures and the unspecific toxicity endpoints such as survival, growth or reproduction. The use of gene expression profiling facilitates the identification of transcriptional changes at the molecular level that are specific to the bio-available fraction of pollutants.
Original languageEnglish
Article number160
JournalBMC Genomics
Volume10
DOIs
Publication statusPublished - 2009

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