Genetic diversity among mycobacterium bovis isolates: A preliminary study of strains from animal and human sources

M. P.U. Sales, G. M. Taylor*, S. Hughes, M. Yates, G. Hewinson, D. B. Young, R. J. Shaw

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

Original languageEnglish
Pages (from-to)4558-4562
Number of pages5
JournalJournal of Clinical Microbiology
Volume39
Issue number12
Early online date01 Dec 2001
DOIs
Publication statusPublished - 17 Dec 2001

Keywords

  • Aged
  • Aged, 80 and over
  • Amidohydrolases/genetics
  • Animals
  • Bacterial Typing Techniques
  • Cats
  • Cattle
  • Female
  • Genetic Variation
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium bovis/classification
  • Oligonucleotides/analysis
  • Phenotype
  • Tuberculosis/microbiology

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