Abstract
Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.
Original language | English |
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Pages (from-to) | 4558-4562 |
Number of pages | 5 |
Journal | Journal of Clinical Microbiology |
Volume | 39 |
Issue number | 12 |
Early online date | 01 Dec 2001 |
DOIs | |
Publication status | Published - 17 Dec 2001 |
Keywords
- Aged
- Aged, 80 and over
- Amidohydrolases/genetics
- Animals
- Bacterial Typing Techniques
- Cats
- Cattle
- Female
- Genetic Variation
- Genotype
- Humans
- Male
- Middle Aged
- Mycobacterium bovis/classification
- Oligonucleotides/analysis
- Phenotype
- Tuberculosis/microbiology