Genetic manipulation of schistosomes - Progress with integration competent vectors

Sutas Suttiprapa, Gabriel Rinaldi, Paul J. Brindley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Citations (SciVal)

Abstract

Draft genome sequences for Schistosoma japonicum and S. mansoni are now available. The schistosome genome encodes ∼13 000 protein-encoding genes for which the functions of few are well understood. Nonetheless, the new genes represent potential intervention targets, and molecular tools are being developed to determine their importance. Over the past 15 years, noteworthy progress has been achieved towards development of tools for gene manipulation and transgenesis of schistosomes. A brief history of genetic manipulation is presented, along with a review of the field with emphasis on reports of integration of transgenes into schistosome chromosomes.

Original languageEnglish
Pages (from-to)641-650
Number of pages10
JournalParasitology
Volume139
Issue number5
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • chromosome integration
  • genetic manipulation
  • germ line
  • murine leukaemia virus
  • piggyBac
  • pseudotyped gammaretrovirus
  • retrovirus
  • Schistosomes
  • transgenesis
  • transposon
  • Gene Transfer Techniques
  • Schistosoma/genetics
  • Animals
  • Life Cycle Stages/genetics
  • RNA Interference
  • Genetic Vectors/genetics
  • Transgenes/genetics

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