TY - JOUR
T1 - Genome sequence of the tsetse fly (Glossina morsitans)
T2 - Vector of African trypanosomiasis
AU - Swain, Martin Thomas
N1 - "This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, Swain, M. T. (2014). Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis. Science, 345(6193), 380-386 . 10.1126/science.1249656
PY - 2014/4/25
Y1 - 2014/4/25
N2 - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein–encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
AB - Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein–encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
KW - Genome sequencing
KW - tsetse fly
UR - http://hdl.handle.net/2160/30341
UR - https://science.sciencemag.org/highwire/filestream/595177/field_highwire_adjunct_files/1/Attardo_SM.pdf
U2 - 10.1126/science.1249656
DO - 10.1126/science.1249656
M3 - Article
SN - 0036-8075
VL - 344
SP - 380
EP - 386
JO - Science
JF - Science
IS - 6182
ER -