TY - JOUR
T1 - Genomes and knowledge - a questionable relationship?
AU - Whitworth, David E.
N1 - Whitworth, D. E. (2008). Genomes and knowledge - a questionable relationship? Trends in Microbiology, 16, (11), pp. 512-519
Article Outline:
* Sequence a genome, annotate, publish and repeat 600 times
* Not all genomes are created equal
* Know thy organism
* Context, context, context
* Changing standards
* A magic number for comparative genomics?
* Ever-diminishing returns?
* Onwards, ever upwards
* Concluding remarks and future perspectives
* Acknowledgements
* References
IMPF: 06.14 RONO: 00
PY - 2008/11/1
Y1 - 2008/11/1
N2 - The availability of bacterial genome sequences has ushered in an era of post-genomic research – accelerating and often enabling molecular genetic analyses. For bacteriologists focussing on an individual bacterium, comparing genomes has also led to a greater understanding of their favoured organism through contextualization. But how does the value of such contextualization vary with the number of available genomes? It seems that for most genome metrics, comparison against approximately 100 genomes is sufficient, with comparison against further genomes not considerably affecting the contextual knowledge gained. It appears that quality, rather than quantity, might be the most important factor when comparing genomes.
AB - The availability of bacterial genome sequences has ushered in an era of post-genomic research – accelerating and often enabling molecular genetic analyses. For bacteriologists focussing on an individual bacterium, comparing genomes has also led to a greater understanding of their favoured organism through contextualization. But how does the value of such contextualization vary with the number of available genomes? It seems that for most genome metrics, comparison against approximately 100 genomes is sufficient, with comparison against further genomes not considerably affecting the contextual knowledge gained. It appears that quality, rather than quantity, might be the most important factor when comparing genomes.
U2 - 10.1016/j.tim.2008.08.001
DO - 10.1016/j.tim.2008.08.001
M3 - Article
SN - 0966-842X
VL - 16
SP - 512
EP - 519
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -