Genomic analysis of Mycobacterium tuberculosis complex strains used for production of purified protein derivative

Jacqueline Inwald, Jason Hinds, Si Palmer, James Dale, Philip D. Butcher, R. Glyn Hewinson, Stephen V. Gordon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)

Abstract

The genomes of the tuberculin production strains Mycobacterium bovis AN5 and Mycobacterium tuberculosis DT were compared to genome-sequenced tubercle bacilli by using DNA microarrays. Neither the AN5 nor DT strain suffered extensive gene deletions during in vitro passage. This suggests that bovine tuberculin made from M. bovis AN5 is suitable to detect infection with presently prevalent M. bovis strains.

Original languageEnglish
Pages (from-to)3929-3932
Number of pages4
JournalJournal of Clinical Microbiology
Volume41
Issue number8
DOIs
Publication statusPublished - 01 Aug 2003

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