Glycomics-driven discoveries in schistosome research

Cornelis H. Hokke; André M. Deelder; Karl F Hoffmann; Manfred Wuhrer

doi:10.1016/j.exppara.2007.06.003

Glycomics-driven discoveries in schistosome research

Cornelis H. Hokke, André M. Deelder, Karl F Hoffmann, Manfred Wuhrer

Department of Life Sciences

Leiden University Medical Center

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes.

Original language	English
Pages (from-to)	275-283
Number of pages	9
Journal	Experimental Parasitology
Volume	117
Issue number	3
Early online date	17 Jun 2007
DOIs	https://doi.org/10.1016/j.exppara.2007.06.003
Publication status	Published - Nov 2007

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title = "Glycomics-driven discoveries in schistosome research",

abstract = "Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes.",

author = "Hokke, {Cornelis H.} and Deelder, {Andr{\'e} M.} and Hoffmann, {Karl F} and Manfred Wuhrer",

note = "Hokke, C. H., Deelder, A. M., Hoffmann, K. F., Wuhrer, M. (2007). Glycomics-driven discoveries in schistosome research. Experimental Parasitology, 117 (3), 275-283.",

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AU - Hokke, Cornelis H.

AU - Deelder, André M.

AU - Hoffmann, Karl F

AU - Wuhrer, Manfred

N1 - Hokke, C. H., Deelder, A. M., Hoffmann, K. F., Wuhrer, M. (2007). Glycomics-driven discoveries in schistosome research. Experimental Parasitology, 117 (3), 275-283.

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N2 - Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes.

AB - Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes.

UR - http://hdl.handle.net/2160/13229

U2 - 10.1016/j.exppara.2007.06.003

DO - 10.1016/j.exppara.2007.06.003

M3 - Article

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SN - 0014-4894

VL - 117

SP - 275

EP - 283

JO - Experimental Parasitology

JF - Experimental Parasitology

IS - 3

ER -

Glycomics-driven discoveries in schistosome research

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