Projects per year
Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications.
|Number of pages||6|
|Publication status||Published - 06 May 2015|
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- Faculty of Business and Physcial Sciences, Department of Physics - Professor, Head of Department (Physics)
Person: Teaching And Research, Other
- 1 Finished
Photoelectron Spectroscopy and Microscopy using Synchrotron Radiation for Exploiting Diamond surfaces and Interfaces
Engineering and Physical Sciences Research Council
01 Oct 2009 → 30 Sept 2013
Project: Externally funded research