Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

OA Olajide, VU Iwuanyanwu, OW Banjo, A Kato, YB Penkova, GWJ Fleet, RJ Nash

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Abstract

Background
Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease.

Methods
A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses.

Results
A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found.

Conclusions
Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.
Original languageEnglish
Article number3342
Number of pages11
JournalMolecules
Volume27
Issue number10
DOIs
Publication statusPublished - 23 May 2022
Externally publishedYes

Keywords

  • (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid
  • Cucumis sativus
  • iminosugar amino acid-idoBR1
  • lipopolysaccharide
  • microglia cell line
  • neuroprotection
  • pro-inflammatory factors

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