Iminosugars from Baphia mitida Lodd

Atsushi Kato; Noriko Kato; Saori Miyauchi; Yuka Minoshima; Isao Adachi; Kyoko Ikeda; Naoki Asano; Alison A. Watson; Robert J. Nash

doi:10.1016/j.phytochem.2007.11.018

Iminosugars from Baphia mitida Lodd

Atsushi Kato, Noriko Kato, Saori Miyauchi, Yuka Minoshima, Isao Adachi, Kyoko Ikeda, Naoki Asano, Alison A. Watson, Robert J. Nash

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

Original language	English
Pages (from-to)	1261-1265
Number of pages	5
Journal	Phytochemistry
Volume	69
Issue number	5
DOIs	https://doi.org/10.1016/j.phytochem.2007.11.018
Publication status	Published - Mar 2008

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10.1016/j.phytochem.2007.11.018

http://hdl.handle.net/2160/2337

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@article{3139a0bc972a468b879d7005c143c81e,

title = "Iminosugars from Baphia mitida Lodd",

abstract = "Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.",

author = "Atsushi Kato and Noriko Kato and Saori Miyauchi and Yuka Minoshima and Isao Adachi and Kyoko Ikeda and Naoki Asano and Watson, {Alison A.} and Nash, {Robert J.}",

note = "Kato, A., Kato, N., Miyauchi, S., Minoshima, Y., Adachi, I., Ikeda, K., Asano, N., Watson, A. A., Nash, R. J. (2008). Iminosugars from Baphia mitida Lodd. Phytochemistry, 69, 1261-1265. Sponsorship: Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Young Scientists, 18790086 and Cooperative Research Center of Life Science . On file IMPF: 02.95 RONO: 00 ",

year = "2008",

month = mar,

doi = "10.1016/j.phytochem.2007.11.018",

language = "English",

volume = "69",

pages = "1261--1265",

journal = "Phytochemistry",

issn = "1873-3700",

publisher = "Elsevier",

number = "5",

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TY - JOUR

T1 - Iminosugars from Baphia mitida Lodd

AU - Kato, Atsushi

AU - Kato, Noriko

AU - Miyauchi, Saori

AU - Minoshima, Yuka

AU - Adachi, Isao

AU - Ikeda, Kyoko

AU - Asano, Naoki

AU - Watson, Alison A.

AU - Nash, Robert J.

N1 - Kato, A., Kato, N., Miyauchi, S., Minoshima, Y., Adachi, I., Ikeda, K., Asano, N., Watson, A. A., Nash, R. J. (2008). Iminosugars from Baphia mitida Lodd. Phytochemistry, 69, 1261-1265. Sponsorship: Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Young Scientists, 18790086 and Cooperative Research Center of Life Science . On file IMPF: 02.95 RONO: 00

PY - 2008/3

Y1 - 2008/3

N2 - Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

AB - Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

U2 - 10.1016/j.phytochem.2007.11.018

DO - 10.1016/j.phytochem.2007.11.018

M3 - Article

C2 - 18191969

SN - 1873-3700

VL - 69

SP - 1261

EP - 1265

JO - Phytochemistry

JF - Phytochemistry

IS - 5

ER -

Iminosugars from Baphia mitida Lodd

Abstract

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