TY - JOUR
T1 - Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG
AU - Vordermeier, H. Martin
AU - Huygen, Kris
AU - Singh, Mahavir
AU - Hewinson, R. Glyn
AU - Xing, Zhou
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.
AB - Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.
UR - http://www.scopus.com/inward/record.url?scp=31844433211&partnerID=8YFLogxK
U2 - 10.1128/IAI.74.2.1416-1418.2006
DO - 10.1128/IAI.74.2.1416-1418.2006
M3 - Article
C2 - 16428796
AN - SCOPUS:31844433211
SN - 0019-9567
VL - 74
SP - 1416
EP - 1418
JO - Infection and Immunity
JF - Infection and Immunity
IS - 2
ER -