Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG

H. Martin Vordermeier*, Kris Huygen, Mahavir Singh, R. Glyn Hewinson, Zhou Xing

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Citations (SciVal)

Abstract

Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

Original languageEnglish
Pages (from-to)1416-1418
Number of pages3
JournalInfection and Immunity
Volume74
Issue number2
Early online date20 Jan 2006
DOIs
Publication statusPublished - 01 Feb 2006

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