Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides

Gareth J. Jones*, Adam Whelan, Derek Clifford, Mick Coad, H. Martin Vordermeier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (SciVal)

Abstract

A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

Original languageEnglish
Pages (from-to)620-622
Number of pages3
JournalClinical and Vaccine Immunology
Volume19
Issue number4
Early online date28 Mar 2012
DOIs
Publication statusPublished - 01 Apr 2012

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