TY - JOUR
T1 - Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides
AU - Jones, Gareth J.
AU - Whelan, Adam
AU - Clifford, Derek
AU - Coad, Mick
AU - Vordermeier, H. Martin
PY - 2012/4/1
Y1 - 2012/4/1
N2 - A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.
AB - A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.
UR - http://www.scopus.com/inward/record.url?scp=84858282907&partnerID=8YFLogxK
U2 - 10.1128/CVI.00024-12
DO - 10.1128/CVI.00024-12
M3 - Article
C2 - 22301696
AN - SCOPUS:84858282907
SN - 1556-6811
VL - 19
SP - 620
EP - 622
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 4
ER -
