Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides

Gareth J. Jones; Adam Whelan; Derek Clifford; Mick Coad; H. Martin Vordermeier

doi:10.1128/CVI.00024-12

Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides

Gareth J. Jones^*
, Adam Whelan
, Derek Clifford
, Mick Coad
, H. Martin Vordermeier

^*Corresponding author for this work

Animal and Plant Health Agency

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

Original language	English
Pages (from-to)	620-622
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	19
Issue number	4
Early online date	28 Mar 2012
DOIs	https://doi.org/10.1128/CVI.00024-12
Publication status	Published - 01 Apr 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1128/CVI.00024-12

Permanent link

Persistent link

Cite this

@article{4001182ddd194192a0125455db35087e,

title = "Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides",

abstract = "A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Gu{\'e}rin (BCG)-vaccinated cattle when used as a skin test reagent for a {"}DIVA{"} test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.",

author = "Jones, \{Gareth J.\} and Adam Whelan and Derek Clifford and Mick Coad and Vordermeier, \{H. Martin\}",

year = "2012",

month = apr,

day = "1",

doi = "10.1128/CVI.00024-12",

language = "English",

volume = "19",

pages = "620--622",

journal = "Clinical and Vaccine Immunology",

issn = "1556-6811",

number = "4",

}

TY - JOUR

T1 - Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides

AU - Jones, Gareth J.

AU - Whelan, Adam

AU - Clifford, Derek

AU - Coad, Mick

AU - Vordermeier, H. Martin

PY - 2012/4/1

Y1 - 2012/4/1

N2 - A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

AB - A peptide cocktail derived from the mycobacterial antigens ESAT-6, CFP-10, and Rv3615c allowed differentiation between Mycobacterium bovis-infected and M. bovis bacillus Calmette-Guérin (BCG)-vaccinated cattle when used as a skin test reagent for a "DIVA" test (i.e., a test capable of differentiating infected and uninfected vaccinated animals). Addition of the antigen Rv3020c improves the diagnostic sensitivity without compromising specificity in the face of BCG or Johne's disease vaccination.

UR - https://www.scopus.com/pages/publications/84858282907

U2 - 10.1128/CVI.00024-12

DO - 10.1128/CVI.00024-12

M3 - Article

C2 - 22301696

AN - SCOPUS:84858282907

SN - 1556-6811

VL - 19

SP - 620

EP - 622

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 4

ER -

Improved skin test for differential diagnosis of bovine tuberculosis by the addition of Rv3020c-derived peptides

Abstract

UN SDGs

Access to Document

Permanent link

Other files and links

Fingerprint

Cite this