Improving the prediction of protein binding sites by combining heterogeneous data and Voronoi diagrams

Joan Segura, Pamela F Jones, Narcis Fernandez-Fuentes

Research output: Contribution to journalArticlepeer-review

39 Citations (SciVal)
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Abstract

Protein binding site prediction by computational means can yield valuable information that complements and guides experimental approaches to determine the structure of protein complexes. Predictions become even more relevant and timely given the current resolution of protein interaction maps, where there is a very large and still expanding gap between the available information on: (i) which proteins interact and (ii) how proteins interact. Proteins interact through exposed residues that present differential physicochemical properties, and these can be exploited to identify protein interfaces.
Original languageEnglish
Pages (from-to)352
JournalBMC Bioinformatics
Volume12
DOIs
Publication statusPublished - 2011

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