In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

Richard A. Williams*, Mark Read, Jon Timmis, Paul S. Andrews, Vipin Kumar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

1 Citation (SciVal)

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

Original languageEnglish
Title of host publicationArtificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
PublisherSpringer Nature
Pages51-54
Number of pages4
ISBN (Print)9783642223709
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event10th International Conference on Artificial Immune Systems, ICARIS 2011 - Cambridge, United Kingdom of Great Britain and Northern Ireland
Duration: 18 Jul 201121 Jul 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6825 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Conference on Artificial Immune Systems, ICARIS 2011
Country/TerritoryUnited Kingdom of Great Britain and Northern Ireland
CityCambridge
Period18 Jul 201121 Jul 2011

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