TY - GEN
T1 - In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis
AU - Williams, Richard A.
AU - Read, Mark
AU - Timmis, Jon
AU - Andrews, Paul S.
AU - Kumar, Vipin
PY - 2011
Y1 - 2011
N2 - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.
AB - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.
UR - http://www.scopus.com/inward/record.url?scp=79960346966&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-22371-6_5
DO - 10.1007/978-3-642-22371-6_5
M3 - Conference Proceeding (Non-Journal item)
AN - SCOPUS:79960346966
SN - 9783642223709
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 51
EP - 54
BT - Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
PB - Springer Nature
T2 - 10th International Conference on Artificial Immune Systems, ICARIS 2011
Y2 - 18 July 2011 through 21 July 2011
ER -
