Increase of tuberculous infection in the organs of B cell-deficient mice

H. M. Vordermeier*, N. Venkataprasad, D. P. Harris, J. Ivanyi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

121 Citations (SciVal)


Protective immunity against infection with Mycobacterium tuberculosis is imparted by T cells rather than antibodies, but B cells can play a role as antigen-presenting cells and in granuloma formation. We re-evaluated the role of B cells in the course of tuberculous infection in μ-chain knock-out (Ig-) mice. Surprisingly, the organs of M. tuberculosis-infected Ig- mice were found to have three- to eight-fold elevated counts of viable bacilli compared with normal littermates at 3-6 weeks post-infection. Splenic interferon-gamma responses to whole antigen were unimpaired, whilst proliferation to certain mycobacterial peptides was found to be diminished. However, bacille Calmette-Guerin (BCG) vaccination significantly reduced the infection in Ig- mice. The mechanisms by which B cells can influence primary tuberculous infection need further study.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalClinical and Experimental Immunology
Issue number2
Publication statusPublished - Nov 1996


  • antibodies
  • B cells
  • mouse infection
  • tuberculosis
  • Enzyme-Linked Immunosorbent Assay
  • T-Lymphocytes/immunology
  • Vaccination
  • Immunoglobulin mu-Chains/genetics
  • B-Lymphocytes/physiology
  • Male
  • Colony Count, Microbial
  • Tuberculosis/etiology
  • Liver/microbiology
  • Mice, Knockout
  • Animals
  • BCG Vaccine/administration & dosage
  • Spleen/metabolism
  • Mycobacterium tuberculosis/isolation & purification
  • Female
  • Lung/microbiology
  • Mice
  • Genes, Immunoglobulin/genetics
  • Cytokines/metabolism
  • Immunologic Deficiency Syndromes/genetics


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