Influence of the nature of the antigen on the boosting of responses to mycobacteria in M. bovis-BCG vaccinated cattle

B. Villarreal-Ramos*, S. Reed, M. McAulay, H. Prentice, T. Coffey, B. C. Charleston, C. J. Howard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (SciVal)

Abstract

Mycobacterium bovis is the causative agent of bovine tuberculosis (TB) and of a proportion of human TB. Protection against TB requires Th1 responses and worsening of disease is associated with Th2 responses. To help clarify the nature of the response to mycobacteria, the responses from M. bovis-BCG vaccinated cattle boosted with live mycobacteria (BCG), bacterial soluble antigens (PPD) or PBS were evaluated. The results indicated that macrophages may be the major cell population ingesting and presenting mycobacteria in BCG boosted animals, while B-cells seem able to ingest and present PPD to T-cells in PPD boosted animals.

Original languageEnglish
Pages (from-to)6850-6858
Number of pages9
JournalVaccine
Volume24
Issue number47-48
Early online date05 Jul 2006
DOIs
Publication statusPublished - 17 Nov 2006

Keywords

  • BCG
  • Cattle
  • DTH
  • Mycobacteria
  • PPD

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