Inhibitory effect of rhetsinine isolated from %IEvodia rutaecarpa$I on aldose reductase activity

Atsushi Kato, H. Yasuko, H. Goto, Jackie Hollinshead, Robert J. Nash, Isao Adachi

Research output: Contribution to journalArticlepeer-review

51 Citations (SciVal)


Aldose reductase inhibitors have considerable potential for the treatment of diabetic complications, without increased risk of hypoglycemia. Search for components inhibiting aldose reductase led to the discovery of active compounds contained in Evodia rutaecarpa Bentham (Rutaceae), which is the one of the component of Kampo-herbal medicine. The hot water extract from the E. rutaecarpa was subjected to distribution or gel filtration chromatography to give an active compound, N2-(2-methylaminobenzoyl)tetrahydro-1H-pyrido[3,4-b]indol-1-one (rhetsinine). It inhibited aldose reductase with IC50 values of 24.1 uM. Furthermore, rhetsinine inhibited sorbitol accumulation by 79.3% at 100 uM. These results suggested that the E. rutaecarpa derived component, rhetsinine, would be potentially useful in the treatment of diabetic complications.
Original languageEnglish
Pages (from-to)258-261
Number of pages4
Issue number2-3
Early online date10 May 2007
Publication statusPublished - 01 Mar 2009


  • Diabetic complications
  • Evodia rutaecarpa
  • Rhetsinine
  • Aldose reductase


Dive into the research topics of 'Inhibitory effect of rhetsinine isolated from %IEvodia rutaecarpa$I on aldose reductase activity'. Together they form a unique fingerprint.

Cite this