Integrating phenotype ontologies across multiple species

Christopher J. Mungall*, Georgios Gkoutos, Cynthia L. Smith, Melissa A. Haendel, Suzanna E. Lewis, Michael Ashburner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

226 Citations (SciVal)
124 Downloads (Pure)

Abstract

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

Original languageEnglish
Article numberR2
Number of pages16
JournalGenome Biology
Volume11
Issue numberR2
DOIs
Publication statusPublished - 08 Jan 2010

Keywords

  • BIOLOGY
  • INFORMATION
  • MODEL
  • SUPPORT
  • HUMAN-GENOME
  • TOOL
  • DATABASE
  • FRAMEWORK
  • ANATOMY
  • EVOLUTION

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