Integrating transcriptome, proteome and glycome analyses of Schistosoma biology

Cornelis H Hokke, Jennifer M Fitzpatrick, Karl F Hoffmann

Research output: Contribution to journalArticlepeer-review

66 Citations (SciVal)

Abstract

Publication of the transcriptomes of Schistosoma mansoni and Schistosoma japonicum, in conjunction with the sequencing and assembly of their genomes, has generated a comprehensive picture of Schistosoma transcriptional and genomic diversity. Subsequently, researchers who study conjugal and developmental biology, tegumental composition and larval or egg, secretory and excretory products have used these data, in combination with the latest '-omics' technologies, to extend large-scale screens of the schistosome transcriptome, proteome and glycome. In this article, we review these postgenomic investigations and contend that the generated datasets provide a plethora of novel drug, vaccine and immunomodulatory targets that might be useful for developing new antischistosome agents.
Original languageEnglish
Pages (from-to)165-174
Number of pages10
JournalTrends in Parasitology
Volume23
Issue number4
Early online date01 Mar 2007
DOIs
Publication statusPublished - Apr 2007

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