Intramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

Zainab Al-Shuhaib; Henning Böckemeier; Lawrence Coghlan; Elina Dörksen; Iestyn V. Jones; Patrick J. Murphy; Robert J. Nash; James M. Page

doi:10.1016/j.tetlet.2013.09.093

Intramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

Zainab Al-Shuhaib, Henning Böckemeier, Lawrence Coghlan, Elina Dörksen, Iestyn V. Jones, Patrick J. Murphy, Robert J. Nash, James M. Page

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The Pd-mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.

Original language	English
Pages (from-to)	6716-6718
Journal	Tetrahedron Letters
Volume	54
Issue number	49
Early online date	27 Sept 2013
DOIs	https://doi.org/10.1016/j.tetlet.2013.09.093
Publication status	Published - 04 Dec 2013

Keywords

guanidine
palladium allylation
heterocyclisation
intramolecular cyclisation

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title = "Intramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines",

abstract = "The Pd-mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.",

keywords = "guanidine, palladium allylation, heterocyclisation, intramolecular cyclisation",

author = "Zainab Al-Shuhaib and Henning B{\"o}ckemeier and Lawrence Coghlan and Elina D{\"o}rksen and Jones, {Iestyn V.} and Murphy, {Patrick J.} and Nash, {Robert J.} and Page, {James M.}",

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doi = "10.1016/j.tetlet.2013.09.093",

language = "English",

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T1 - Intramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

AU - Al-Shuhaib, Zainab

AU - Böckemeier, Henning

AU - Coghlan, Lawrence

AU - Dörksen, Elina

AU - Jones, Iestyn V.

AU - Murphy, Patrick J.

AU - Nash, Robert J.

AU - Page, James M.

PY - 2013/12/4

Y1 - 2013/12/4

N2 - The Pd-mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.

AB - The Pd-mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines 4 and 14b led to the formation of five- and six-membered heterocycles 5 and 17 in high yields.

KW - guanidine

KW - palladium allylation

KW - heterocyclisation

KW - intramolecular cyclisation

UR - http://hdl.handle.net/2160/36363

U2 - 10.1016/j.tetlet.2013.09.093

DO - 10.1016/j.tetlet.2013.09.093

M3 - Article

SN - 0040-4039

VL - 54

SP - 6716

EP - 6718

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 49

ER -

Intramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines

Abstract

Keywords

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