Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

Laurence Jones, Jackie Hollinshead, George W. J. Fleet, Amber L. Thompson, David J. Watkin, Zoltan A. Gal, Sarah F. Jenkinson, Atsushi Kato, Robert J. Nash

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)


The Australian leguminous tree Castanospermum australe contains the anti-viral glucose analogue indolizidine alkaloid castanospermine. As the result of a search for new bioactive carbohydrate-like compounds we now report the isolation of the novel polyhydroxylated pyrrolizidine alkaloid, 1-epialexine, from the leaves and stems of C. australe. 1-Epialexine is a weak inhibitor of β-mannosidase from Cellullomonas fimi.
Original languageEnglish
Pages (from-to)133-135
Number of pages3
JournalPhytochemistry Letters
Issue number3
Publication statusPublished - Sept 2010


  • 1-Epialexine
  • isolation
  • pyrrolizidine
  • castanospermum australe
  • fabaceae


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