Labelled compounds of interest as antitumour agents-VII1. [2H]- and [14C]-curcumin

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Curcumin (E,E-1,7-di(4-hydroxy-3-methoxyphenyl)-3-hydroxyhepta-1,3,6-trien-5-one) is an investigational cancer chemopreventive agent. Lithium-bromine exchange of 1-bromo-4-(1-ethoxyethyl)-3-methoxybenzene with butyl lithium, quench with O2HCNMe2 and acidic work-up gave 4-hydroxy-3-methoxybenz-[2H]-aldehyde ([2H]-vanillin) in 27% yield (based on O2HCNMe2). Condensation with pentane-2,4-dione then gave E,E-1,7-di(4-hydroxy-3-methoxyphenyl)-3-hydroxy-1,7-di-[2H]-hepta-1,3,6-trien-5 one ([2H2]-curcumin). Adaptation of the procedures and use of OH14CNMe2 provided [14C]-curcumin (specific radioactivity 12·7 MBq mmol−1) via [14C]-vanillin.
Original languageEnglish
Pages (from-to)883-889
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number9
Publication statusPublished - Aug 2000
Externally publishedYes


  • C
  • Curcumin
  • Dimethylformamide
  • H
  • Lithiation
  • Vanillin


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