Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP

Robert J. Nash, Naoki Asano, Ana L. Winters, C. Y. Yu, George W. J. Fleet, T. D. Butters, Kyoko Ikeda, R. A. Dwek, M. R. Wormald, M. X. Wang

Research output: Contribution to journalArticlepeer-review

68 Citations (SciVal)

Abstract

L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian -glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast -glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition.
Original languageEnglish
Pages (from-to)1936-1937
Number of pages2
JournalChemical Communications
DOIs
Publication statusPublished - 29 Jul 2004

Fingerprint

Dive into the research topics of 'Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP'. Together they form a unique fingerprint.

Cite this