Projects per year
now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples.
Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive.
These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome
- Lung cancer
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- 1 Finished
Huws, S., Creevey, C., Kingston-Smith, A., McEwan, N. & Newbold, C.
01 Apr 2014 → 31 Mar 2018
Project: Externally funded research