Mechanism of plasma glutathione peroxidase production in bovine adipocytes

Tadashi Yamasaki, Koji Tahara, Shoichi Takano, Miho Inoue-Murayama, Michael T. Rose, Takeshi Minashima, Hisashi Aso, Shin'ichi Ito

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15 Citations (SciVal)


Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are expressed following adipocyte differentiation in a bovine intramuscular preadipocyte (BIP) line. Therefore, we have analyzed the mechanism of production of pGPx in adipocytes. The expression of pGPx and C/EBPδ increases during adipogenesis, with dexamethasone being the main effector of these genes. The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells. The production of pGPx in bovine tissues is greatest in kidney and in intraperitoneal fat. We consider that the transcriptional control of pGPx in cattle might be carried out by C/EBPδ and that the expression of pGPx might be a characteristic phenomenon of bovine adipogenesis.
Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalCell and Tissue Research
Issue number1
Early online date31 May 2006
Publication statusPublished - 01 Oct 2006


  • adipocyte
  • BIP cell
  • C/EBPδ
  • pGPx
  • bovine


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