Modelling and simulation of granuloma formation in visceral leishmaniasis

Anton Jakob Flügge, Jon Timmis*, Paul Andrews, John Moore, Paul Kaye

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

15 Citations (SciVal)

Abstract

Visceral leishmaniasis is a parasitic disease that is usually fatal if untreated. Host resistance is thought to involve the accumulation of inflammatory cells into structures called granulomas. To date, the possible processes underlying granuloma formation are not fully understood. The importance of modelling in immunology is increasing particularly for dynamic processes that are hard to study in vivo over extended periods of time. Appropriate modelling can provide novel insights that might help deepen the understanding of phenomena and/or help guide experimental work. This paper discusses initial studies on the regulation of granuloma using a combination of UML like modelling and agent based simulation.

Original languageEnglish
Title of host publication2009 IEEE Congress on Evolutionary Computation, CEC 2009
Pages3052-3059
Number of pages8
DOIs
Publication statusPublished - 2009
Event2009 IEEE Congress on Evolutionary Computation, CEC 2009 - Trondheim, Norway
Duration: 18 May 200921 May 2009

Publication series

Name2009 IEEE Congress on Evolutionary Computation, CEC 2009

Conference

Conference2009 IEEE Congress on Evolutionary Computation, CEC 2009
Country/TerritoryNorway
CityTrondheim
Period18 May 200921 May 2009

Keywords

  • immune system
  • biological system modeling
  • cells (biology)
  • parasitic diseases
  • unified modeling language
  • computational modeling
  • Computer Simulation
  • computer science
  • systems biology
  • computer simulation
  • computational biology

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