Modulation of toll-like receptor activity by leukocyte ig-like receptors and their effects during bacterial infection

Louise E. Pilsbury, Rachel L. Allen, Martin Vordermeier

Research output: Contribution to journalReview articlepeer-review

21 Citations (SciVal)

Abstract

Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. Here we describe the LILR family, their inhibitory effect on TLR activity in cells of the monocytic lineage, their signalling pathway, and their antimicrobial effects during bacterial infection. Agents have already been identified which enhances or inhibits LILR activity raising the future possibility that modulation of LILR function could be used as a means to modulate TLR activity.

Original languageEnglish
Article number536478
JournalMediators of Inflammation
Volume2010
Early online date20 Jun 2010
DOIs
Publication statusPublished - 19 Jul 2010

Fingerprint

Dive into the research topics of 'Modulation of toll-like receptor activity by leukocyte ig-like receptors and their effects during bacterial infection'. Together they form a unique fingerprint.

Cite this