Molecular epidemiology of bovine tuberculosis II. Applications of genotyping

P. A. Durr*, R. S. Clifton-Hadley, R. G. Hewinson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (SciVal)

Abstract

The applications of genotyping of Mycobacterium bovis are reviewed. Published research to date has been conducted predominantly within the context of validating typing methods, and few studies have been specifically epidemiological. This is contrasted with the situation in human tuberculosis, where the application of restriction fragment length polymorphism typing using insertion sequence IS6110 has successfully led to insights into the epidemiology and molecular evolution of the pathogen. Based upon the medical experience, the adoption of an integrated approach which combines epidemiology and molecular biology is recommended for future studies. Accordingly, clear identification and explanation of type clustering should be possible, which should facilitate decisions related to disease control.

Original languageEnglish
Pages (from-to)689-701
Number of pages13
JournalOIE Revue Scientifique et Technique
Volume19
Issue number3
DOIs
Publication statusPublished - 01 Dec 2000

Keywords

  • Genotyping
  • Molecular epidemiology
  • Mycobacterium bovis
  • Restriction endonuclease analysis
  • Restriction fragment length polymorphism
  • Spoligotyping
  • Tuberculosis
  • Animals, Zoo
  • Humans
  • Virulence
  • Disease Reservoirs/veterinary
  • Genotype
  • Animals, Domestic
  • Animals, Wild
  • Mycobacterium bovis/classification
  • Animals
  • Cattle
  • Tuberculosis, Bovine/epidemiology
  • Models, Genetic
  • Zoonoses/epidemiology
  • Disease Outbreaks/veterinary
  • Molecular Epidemiology/trends
  • Research/trends

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