Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans

Louise E. Docherty, Faisal I. Rezwan, Rebecca L. Poole, Claire L. S. Turner, Emma Kivuva, E.R. Maher, Sarah F. Smithson, Julian P. Hamilton-Shield, Michal Patalan, Maria Gizewska, Jaroslaw Peregud-Pogorzelski, Jasmin Beygo, Karin Buiting, Bernhard Horsthemke, Lukas Soellner, M. Begemann, T. Eggermann, Emma Baple, S. Mansour, I. Kare TempleDeborah J. G. MacKay

Research output: Contribution to journalArticlepeer-review

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Human-imprinting disorders are congenital disorders of growth, development and metabolism, associated with disturbance of parent of origin-specific DNA methylation at imprinted loci across the genome. Some imprinting disorders have higher than expected prevalence of monozygotic twinning, of assisted reproductive technology among parents, and of disturbance of multiple imprinted loci, for which few causative trans-acting mutations have been found. Here we report mutations in NLRP5 in five mothers of individuals affected by multilocus imprinting disturbance. Maternal-effect mutations of other human NLRP genes, NLRP7 and NLRP2, cause familial biparental hydatidiform mole and multilocus imprinting disturbance, respectively. Offspring of mothers with NLRP5 mutations have heterogenous clinical and epigenetic features, but cases include a discordant monozygotic twin pair, individuals with idiopathic developmental delay and autism, and families affected by infertility and reproductive wastage. NLRP5 mutations suggest connections between maternal reproductive fitness, early zygotic development and genomic imprinting.
Original languageEnglish
Article number8086
JournalNature Communications
Publication statusPublished - 01 Sept 2015


  • Abortion, Spontaneous/genetics
  • Adolescent
  • Adult
  • Autistic Disorder/genetics
  • Autoantigens/genetics
  • Beckwith-Wiedemann Syndrome/genetics
  • Computer Simulation
  • DNA Copy Number Variations
  • DNA Methylation
  • Diabetes Mellitus/genetics
  • Epigenesis, Genetic
  • Female
  • Genomic Imprinting/genetics
  • Humans
  • Hydatidiform Mole/genetics
  • Infant, Newborn, Diseases/genetics
  • Infertility, Female/genetics
  • Male
  • Mitochondrial Proteins
  • Mothers
  • Mutation
  • Nuclear Proteins
  • Obesity/genetics
  • Polymerase Chain Reaction
  • Pregnancy
  • Sequence Analysis, DNA
  • Silver-Russell Syndrome/genetics
  • Twins, Monozygotic
  • Uterine Neoplasms/genetics
  • Young Adult


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