Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Martin Vordermeier; Stephen V. Gordon; R. Glyn Hewinson

doi:10.1016/j.vetmic.2011.02.020

Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Martin Vordermeier^*, Stephen V. Gordon, R. Glyn Hewinson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

Original language	English
Pages (from-to)	8-13
Number of pages	6
Journal	Veterinary Microbiology
Volume	151
Issue number	1-2
Early online date	24 Feb 2011
DOIs	https://doi.org/10.1016/j.vetmic.2011.02.020
Publication status	Published - 05 Jul 2011

Keywords

Antigen reagents
BCG
Differential diagnosis
DIVA
Mycobacterium bovis
Mycobacterium tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vetmic.2011.02.020

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AU - Hewinson, R. Glyn

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AB - The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

KW - Antigen reagents

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KW - Differential diagnosis

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KW - Mycobacterium bovis

KW - Mycobacterium tuberculosis

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Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Abstract

Keywords

UN SDGs

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