Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Martin Vordermeier*, Stephen V. Gordon, R. Glyn Hewinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (SciVal)

Abstract

The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalVeterinary Microbiology
Volume151
Issue number1-2
Early online date24 Feb 2011
DOIs
Publication statusPublished - 05 Jul 2011

Keywords

  • Antigen reagents
  • BCG
  • Differential diagnosis
  • DIVA
  • Mycobacterium bovis
  • Mycobacterium tuberculosis

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