Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity

Janice J. Endsley; Alison Hogg; Lis J. Shell; Martin McAulay; Tracey Coffey; Chris Howard; Charles F. Capinos Scherer; W. Ray Waters; Brian Nonnecke; D. Mark Estes; Bernardo Villarreal-Ramos

doi:10.1016/j.vaccine.2007.10.011

Mycobacterium bovis BCG vaccination induces memory CD4⁺ T cells characterized by effector biomarker expression and anti-mycobacterial activity

Janice J. Endsley
, Alison Hogg
, Lis J. Shell
, Martin McAulay
, Tracey Coffey
, Chris Howard
, Charles F. Capinos Scherer
, W. Ray Waters
, Brian Nonnecke
, D. Mark Estes
, Bernardo Villarreal-Ramos^*

^*Corresponding author for this work

Bovine TB, diseases and control

The University of Texas Medical Branch at Galveston
Animal Health Institute
Unité de recherche sur les maladies cardiovasculaires et métaboliques

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The effector mechanisms used by CD4⁺ T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4⁺ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Antigenic stimulation of peripheral blood CD4⁺ T cells from BCG-vaccinated cattle enhanced expression of perforin and IFNγ in cells expressing a CD45RA^-CD45RO⁺CD62L⁺ cell surface phenotype, enhanced transcription of granulysin, IFNγ, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4⁺ T cells against BCG-infected macrophages.

Original language	English
Pages (from-to)	8384-8394
Number of pages	11
Journal	Vaccine
Volume	25
Issue number	50
Early online date	23 Oct 2007
DOIs	https://doi.org/10.1016/j.vaccine.2007.10.011
Publication status	Published - 05 Dec 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CD4 T cells
Cytotoxicity
Tuberculosis

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10.1016/j.vaccine.2007.10.011

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Cite this

Endsley, J. J., Hogg, A., Shell, L. J., McAulay, M., Coffey, T., Howard, C., Capinos Scherer, C. F., Waters, W. R., Nonnecke, B., Estes, D. M., & Villarreal-Ramos, B. (2007). Mycobacterium bovis BCG vaccination induces memory CD4⁺ T cells characterized by effector biomarker expression and anti-mycobacterial activity. Vaccine, 25(50), 8384-8394. https://doi.org/10.1016/j.vaccine.2007.10.011

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title = "Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity",

abstract = "The effector mechanisms used by CD4+ T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Gu{\'e}rin (BCG). Antigenic stimulation of peripheral blood CD4+ T cells from BCG-vaccinated cattle enhanced expression of perforin and IFNγ in cells expressing a CD45RA-CD45RO+CD62L+ cell surface phenotype, enhanced transcription of granulysin, IFNγ, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4+ T cells against BCG-infected macrophages.",

keywords = "CD4 T cells, Cytotoxicity, Tuberculosis",

author = "Endsley, \{Janice J.\} and Alison Hogg and Shell, \{Lis J.\} and Martin McAulay and Tracey Coffey and Chris Howard and \{Capinos Scherer\}, \{Charles F.\} and Waters, \{W. Ray\} and Brian Nonnecke and Estes, \{D. Mark\} and Bernardo Villarreal-Ramos",

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Endsley, JJ, Hogg, A, Shell, LJ, McAulay, M, Coffey, T, Howard, C, Capinos Scherer, CF, Waters, WR, Nonnecke, B, Estes, DM & Villarreal-Ramos, B 2007, 'Mycobacterium bovis BCG vaccination induces memory CD4⁺ T cells characterized by effector biomarker expression and anti-mycobacterial activity', Vaccine, vol. 25, no. 50, pp. 8384-8394. https://doi.org/10.1016/j.vaccine.2007.10.011

TY - JOUR

T1 - Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity

AU - Endsley, Janice J.

AU - Hogg, Alison

AU - Shell, Lis J.

AU - McAulay, Martin

AU - Coffey, Tracey

AU - Howard, Chris

AU - Capinos Scherer, Charles F.

AU - Waters, W. Ray

AU - Nonnecke, Brian

AU - Estes, D. Mark

AU - Villarreal-Ramos, Bernardo

PY - 2007/12/5

Y1 - 2007/12/5

N2 - The effector mechanisms used by CD4+ T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Antigenic stimulation of peripheral blood CD4+ T cells from BCG-vaccinated cattle enhanced expression of perforin and IFNγ in cells expressing a CD45RA-CD45RO+CD62L+ cell surface phenotype, enhanced transcription of granulysin, IFNγ, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4+ T cells against BCG-infected macrophages.

AB - The effector mechanisms used by CD4+ T cells to control mycobacteria differ between humans and rodent models of TB and should be investigated in additional animal models. In these studies, the bovine model was used to characterize the mycobactericidal CD4+ T cell response induced by vaccination with the attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Antigenic stimulation of peripheral blood CD4+ T cells from BCG-vaccinated cattle enhanced expression of perforin and IFNγ in cells expressing a CD45RA-CD45RO+CD62L+ cell surface phenotype, enhanced transcription of granulysin, IFNγ, perforin, IL-4, IL-13, and IL-21, and enhanced anti-mycobacterial activity of CD4+ T cells against BCG-infected macrophages.

KW - CD4 T cells

KW - Cytotoxicity

KW - Tuberculosis

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DO - 10.1016/j.vaccine.2007.10.011

M3 - Article

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