Negative mood reverses devaluation of goal-directed drug-seeking favouring an incentive learning account of drug dependence.

Lee Hogarth, Zhimin He, Henry W. Chase, Andy J. Wills, Joseph Troisi II, Adam M. Leventhal, Amanda R. Mathew, Brian Hitsman

Research output: Contribution to journalArticlepeer-review

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Abstract

Background
Two theories explain how negative mood primes smoking behaviour. The stimulus–response (S-R) account argues that in the negative mood state, smoking is experienced as more reinforcing, establishing a direct (automatic) association between the negative mood state and smoking behaviour. By contrast, the incentive learning account argues that in the negative mood state smoking is expected to be more reinforcing, which integrates with instrumental knowledge of the response required to produce that outcome.

Objectives
One differential prediction is that whereas the incentive learning account anticipates that negative mood induction could augment a novel tobacco-seeking response in an extinction test, the S-R account could not explain this effect because the extinction test prevents S-R learning by omitting experience of the reinforcer.

Methods
To test this, overnight-deprived daily smokers (n = 44) acquired two instrumental responses for tobacco and chocolate points, respectively, before smoking to satiety. Half then received negative mood induction to raise the expected value of tobacco, opposing satiety, whilst the remainder received positive mood induction. Finally, a choice between tobacco and chocolate was measured in extinction to test whether negative mood could augment tobacco choice, opposing satiety, in the absence of direct experience of tobacco reinforcement.

Results
Negative mood induction not only abolished the devaluation of tobacco choice, but participants with a significant increase in negative mood increased their tobacco choice in extinction, despite satiety.

Conclusions
These findings suggest that negative mood augments drug-seeking by raising the expected value of the drug through incentive learning, rather than through automatic S-R control.
Original languageEnglish
Pages (from-to)3235-3247
Number of pages23
JournalPsychopharmacology
Volume232
Issue number17
DOIs
Publication statusPublished - 05 Jun 2015

Keywords

  • incentive learning
  • goal-directed learning
  • drug-seeking
  • negative mood
  • depression
  • allostasis
  • discriminative stimuli
  • motivating operations
  • negative reinforcement

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