TY - JOUR
T1 - Peptide-specific T cell response to Mycobacterium tuberculosis
T2 - Clinical spectrum, compartmentalization, and effect of chemotherapy
AU - Wilkinson, Robert John
AU - Vordermeier, Hans Martin
AU - Wilkinson, Katalin Andrea
AU - Sjölund, Ann
AU - Moreno, Carlos
AU - Pasvol, Geoffrey
AU - Ivanyi, Juraj
PY - 1998/9/1
Y1 - 1998/9/1
N2 - The T cell repertoire of 59 patients with untreated tuberculosis was compared with that of 46 bacille Calmette-Guerin-vaccinated controls by assaying the proliferative responses to six permissively recognized peptides from the 16-, 19-, and 38-kDa molecules of Mycobacterium tuberculosis. A trend from higher to lower reactivity following this order: vaccinated controls > lymph node disease > localized extrapulmonary > pulmonary > pleural was seen for 4 of the peptides (P < .03). The decreased response of blood lymphocytes from patients with pleural tuberculosis was partially accounted for by sequestration of peptide-responsive cells within the pleural fluid. Chemotherapy 'reversed' the depressed proliferative responses of patients with pulmonary and pleural tuberculosis depending on the peptide origin, being greatest for peptides of 16 kDa, transient for those of 19 kDa, and least for those of 38 kDa. These data demonstrate antigen specificity in the decreased responsiveness of patients with tuberculosis.
AB - The T cell repertoire of 59 patients with untreated tuberculosis was compared with that of 46 bacille Calmette-Guerin-vaccinated controls by assaying the proliferative responses to six permissively recognized peptides from the 16-, 19-, and 38-kDa molecules of Mycobacterium tuberculosis. A trend from higher to lower reactivity following this order: vaccinated controls > lymph node disease > localized extrapulmonary > pulmonary > pleural was seen for 4 of the peptides (P < .03). The decreased response of blood lymphocytes from patients with pleural tuberculosis was partially accounted for by sequestration of peptide-responsive cells within the pleural fluid. Chemotherapy 'reversed' the depressed proliferative responses of patients with pulmonary and pleural tuberculosis depending on the peptide origin, being greatest for peptides of 16 kDa, transient for those of 19 kDa, and least for those of 38 kDa. These data demonstrate antigen specificity in the decreased responsiveness of patients with tuberculosis.
UR - http://www.scopus.com/inward/record.url?scp=0031711468&partnerID=8YFLogxK
U2 - 10.1086/515336
DO - 10.1086/515336
M3 - Article
C2 - 9728545
AN - SCOPUS:0031711468
SN - 0022-1899
VL - 178
SP - 760
EP - 768
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
