@article{e6f5d36c511543738fb583e17e74ee56,
title = "Perspective: Dietary Biomarkers of Intake and Exposure - Exploration with Omics Approaches",
abstract = "While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research",
keywords = "dietary biomarkers, dietary intervention studies, diet, nutrition, metabolomics, Metagenomics, Reproducibility of Results, Biomarkers/analysis, Genomics, Humans, Nutritional Physiological Phenomena/genetics, Diet, Nutritional Sciences/methods, Nutritional Status, Metabolomics/methods, Food",
author = "Padma Maruvada and Lampe, {Johanna W.} and Wishart, {David S.} and Dinesh Barupal and Chester, {Deirdra N.} and Dylan Dodd and Yannick Djoumbou-Feunang and Dorrestein, {Pieter C.} and Dragsted, {Lars O.} and John Draper and Duffy, {Linda C.} and Dwyer, {Johanna T.} and Emenaker, {Nancy J.} and Oliver Fiehn and Gerszten, {Robert E.} and Hu, {Frank B.} and Karp, {Robert W.} and Klurfeld, {David M.} and Laughlin, {Maren R.} and Little, {A. Roger} and Lynch, {Christopher J.} and Moore, {Steven C.} and Nicastro, {Holly L.} and O'Brien, {Diane M.} and Ordov{\'a}s, {Jos{\'e} M.} and Osganian, {Stavroula K.} and Mary Playdon and Ross Prentice and Daniel Raftery and Nichole Reisdorph and Roche, {Helen M.} and Ross, {Sharon A.} and Shengmin Sang and Augustin Scalbert and Srinivas, {Pothur R.} and Zeisel, {Steven H.}",
note = "Funding Information: Perspective articles allow authors to take a position on a topic of current major importance or controversy in the field of nutrition. As such, these articles could include statements based on author opinions or point of view. Opinions expressed in Perspective articles are those of the author and are not attributable to the funder(s) or the sponsor(s) or the publisher, Editor, or Editorial Board of Advances in Nutrition. Individuals with different positions on the topic of a Perspective are invited to submit their comments in the form of a Perspectives article or in a Letter to the Editor. The workshop was supported by the funds from National Institute of Diabetes and Digestive and Kidney Diseases. Disclaimer: Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of the International Agency for Research on Cancer/World Health Organization. Author disclosures: PM, JWL, DSW, DB, DNC, DD, YD-F, PCD, LOD, JD, LCD, JTD, NJE, OF, REG, FBH, RWK, DMK, MRL, ARL, CJL, SCM, HLN, DMO, JMO, SKO, MP, RP, DR, NR, HMR, SAR, SS, AS, and PRS, no conflicts of interest. SHZ has an equity interest in SNP therapeutics, a company that identifies people with certain genetic polymorphisms that are associated with health problems and develops medical foods to treat these problems. He has had grant funding from Balchem Company, a company that makes choline for diet supplements and animal feed. SHZ is on advisory boards for Baxter, Procter and Gamble, and Abbott, all companies with an interest in choline relative to their products. He received an honorarium for speaking from Nutrapharma, a company that makes diet supplements. Address correspondence to PM (e-mail: padma.maruvada@nih.gov) or JWL (e-mail: jlampe@fredhutch.org). Abbreviations used: AUROC, area under the receiver operating characteristic curve; BFI, biomarker of food intake; CFS, controlled feeding study; DLW, doubly labeled water; DPB, dietary pattern biomarker; FCIB, food component intake biomarker; FoodBAll, Food Biomarker Alliance; IRMS, isotope ratio mass spectrometry; MoNA, MassBank of North America; MWAS, metabolome-wide association study; PEMT, phosphatidyl ethanolamine-N-methyltransferase; ROC, receiver operating characteristic; SIR, stable isotope ratio; SNP, single-nucleotide polymorphism. Publisher Copyright: {\textcopyright} 2019 Published by Oxford University Press on behalf of the American Society for Nutrition 2019.",
year = "2020",
month = mar,
day = "1",
doi = "10.1093/advances/nmz075",
language = "English",
volume = "11",
pages = "200--215",
journal = "Advances in Nutrition",
issn = "2156-5376",
publisher = "Oxford University Press",
number = "2",
}
