Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

Naoki Asano, George W. J. Fleet, Alison A. Watson, Russell J. Molyneux, Robert J. Nash

Research output: Contribution to journalArticlepeer-review

730 Citations (SciVal)


Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.
Original languageEnglish
Pages (from-to)265-295
Number of pages31
Issue number3
Publication statusPublished - 21 Feb 2001


  • Glycosidase
  • Indolizidines
  • Inhibitors
  • N-Containing sugars
  • Nortropanes
  • Piperidines
  • Pyrrolidines
  • Pyrrolizidines


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