Presaging critical residues in protein interfaces-web server (PCRPi-W): a web server to chart hot spots in protein interfaces

Joan Segura Mora, Salam A Assi, Narcis Fernandez-Fuentes

Research output: Contribution to journalArticlepeer-review

23 Citations (SciVal)
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Abstract

It is well established that only a portion of residues that mediate protein-protein interactions (PPIs), the so-called hot spot, contributes the most to the total binding energy, and thus its identification is an important and relevant question that has clear applications in drug discovery and protein design. The experimental identification of hot spots is however a lengthy and costly process, and thus there is an interest in computational tools that can complement and guide experimental efforts.
Original languageEnglish
Pages (from-to)e12352
JournalPLoS One
Volume5
Issue number8
DOIs
Publication statusPublished - 2010

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