Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family

N. R. McEwan; Sylvain C. P. Eschenlauer; Roger E. Calza; R. J. Wallace; C. J. Newbold

doi:10.1016/S1434-4610(99)70028-3

Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family

N. R. McEwan, Sylvain C. P. Eschenlauer, Roger E. Calza, R. J. Wallace, C. J. Newbold

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The phylogenetic position of eleven 14-3-3 proteins from five protozoal species was tested relative to other eukaryotic 14-3-3 versions representing many of the previously described isoforms, The protozoal proteins, four from Entodinium caudatum, three from Entameoba histolytica and four from api-complexan parasites formed clusters closer to the plant and animal epsilon isoforms than to the animal beta, gamma/eta, sigma/theta, and zeta isoforms. This extends the preliminary findings of Wang and Shakes (1996) but data from a wider range of genera are still required to strengthen our hypothesis that the protozoan isoforms may constitute novel isoforms of the 14-3-3 family.

Original language	English
Pages (from-to)	257-264
Number of pages	8
Journal	Protist
Volume	150
Issue number	3
DOIs	https://doi.org/10.1016/S1434-4610(99)70028-3
Publication status	Published - Oct 1999

Keywords

DISTRIBUTIONS
14-3-3-PROTEINS
REGULATORS
HOMOLOG
BRAIN
RUMEN
KINASE-C
MOLECULAR-CLONING
EXPRESSION
BINDING COMPLEX

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title = "Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family",

abstract = "The phylogenetic position of eleven 14-3-3 proteins from five protozoal species was tested relative to other eukaryotic 14-3-3 versions representing many of the previously described isoforms, The protozoal proteins, four from Entodinium caudatum, three from Entameoba histolytica and four from api-complexan parasites formed clusters closer to the plant and animal epsilon isoforms than to the animal beta, gamma/eta, sigma/theta, and zeta isoforms. This extends the preliminary findings of Wang and Shakes (1996) but data from a wider range of genera are still required to strengthen our hypothesis that the protozoan isoforms may constitute novel isoforms of the 14-3-3 family.",

keywords = "DISTRIBUTIONS, 14-3-3-PROTEINS, REGULATORS, HOMOLOG, BRAIN, RUMEN, KINASE-C, MOLECULAR-CLONING, EXPRESSION, BINDING COMPLEX",

author = "McEwan, {N. R.} and Eschenlauer, {Sylvain C. P.} and Calza, {Roger E.} and Wallace, {R. J.} and Newbold, {C. J.}",

note = "McEwan, N. R., Eschenlauer, S. C. P., Calza, R. E., Wallace, R. J., Newbold, C. J. (1999). Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family. Protist, 150 (3), 257-264.",

year = "1999",

month = oct,

doi = "10.1016/S1434-4610(99)70028-3",

language = "English",

volume = "150",

pages = "257--264",

journal = "Protist",

issn = "1434-4610",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family

AU - McEwan, N. R.

AU - Eschenlauer, Sylvain C. P.

AU - Calza, Roger E.

AU - Wallace, R. J.

AU - Newbold, C. J.

N1 - McEwan, N. R., Eschenlauer, S. C. P., Calza, R. E., Wallace, R. J., Newbold, C. J. (1999). Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family. Protist, 150 (3), 257-264.

PY - 1999/10

Y1 - 1999/10

N2 - The phylogenetic position of eleven 14-3-3 proteins from five protozoal species was tested relative to other eukaryotic 14-3-3 versions representing many of the previously described isoforms, The protozoal proteins, four from Entodinium caudatum, three from Entameoba histolytica and four from api-complexan parasites formed clusters closer to the plant and animal epsilon isoforms than to the animal beta, gamma/eta, sigma/theta, and zeta isoforms. This extends the preliminary findings of Wang and Shakes (1996) but data from a wider range of genera are still required to strengthen our hypothesis that the protozoan isoforms may constitute novel isoforms of the 14-3-3 family.

AB - The phylogenetic position of eleven 14-3-3 proteins from five protozoal species was tested relative to other eukaryotic 14-3-3 versions representing many of the previously described isoforms, The protozoal proteins, four from Entodinium caudatum, three from Entameoba histolytica and four from api-complexan parasites formed clusters closer to the plant and animal epsilon isoforms than to the animal beta, gamma/eta, sigma/theta, and zeta isoforms. This extends the preliminary findings of Wang and Shakes (1996) but data from a wider range of genera are still required to strengthen our hypothesis that the protozoan isoforms may constitute novel isoforms of the 14-3-3 family.

KW - DISTRIBUTIONS

KW - 14-3-3-PROTEINS

KW - REGULATORS

KW - HOMOLOG

KW - BRAIN

KW - RUMEN

KW - KINASE-C

KW - MOLECULAR-CLONING

KW - EXPRESSION

KW - BINDING COMPLEX

UR - http://hdl.handle.net/2160/9387

U2 - 10.1016/S1434-4610(99)70028-3

DO - 10.1016/S1434-4610(99)70028-3

M3 - Article

SN - 1434-4610

VL - 150

SP - 257

EP - 264

JO - Protist

JF - Protist

IS - 3

ER -

Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family

Abstract

Keywords

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