Protozoal sequences may reveal additional isoforms of the 14-3-3 protein family

N. R. McEwan, Sylvain C. P. Eschenlauer, Roger E. Calza, R. J. Wallace, C. J. Newbold

Research output: Contribution to journalArticlepeer-review

7 Citations (SciVal)

Abstract

The phylogenetic position of eleven 14-3-3 proteins from five protozoal species was tested relative to other eukaryotic 14-3-3 versions representing many of the previously described isoforms, The protozoal proteins, four from Entodinium caudatum, three from Entameoba histolytica and four from api-complexan parasites formed clusters closer to the plant and animal epsilon isoforms than to the animal beta, gamma/eta, sigma/theta, and zeta isoforms. This extends the preliminary findings of Wang and Shakes (1996) but data from a wider range of genera are still required to strengthen our hypothesis that the protozoan isoforms may constitute novel isoforms of the 14-3-3 family.

Original languageEnglish
Pages (from-to)257-264
Number of pages8
JournalProtist
Volume150
Issue number3
DOIs
Publication statusPublished - Oct 1999

Keywords

  • DISTRIBUTIONS
  • 14-3-3-PROTEINS
  • REGULATORS
  • HOMOLOG
  • BRAIN
  • RUMEN
  • KINASE-C
  • MOLECULAR-CLONING
  • EXPRESSION
  • BINDING COMPLEX

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